一例孕期慢性粒细胞白血病，其特征为复杂易位t(9;22;11)(q34;q11.2;q13) 。
A case of chronic myelogenous leukemia in pregnancy characterized by a complex translocation t(9;22;11)(q34;q11.2;q13).
作者信息
Kumar Surachit, Apostolova Mariya, Woolley Paul V
机构信息
Department of Medicine and Conemaugh Cancer Care Center, Johnstown, Pennsylvania, USA.
出版信息
Hematol Rep. 2011 Oct 19;3(3):e27. doi: 10.4081/hr.2011.e27. Epub 2011 Nov 21.
The management of chronic myelogenous leukemia during pregnancy requires balancing the well-being of the mother with that of the fetus. We report a case of a 26-year-old lady who was diagnosed with chronic myelogenous leukemia (CML) at 15 weeks gestation and who had an atypical chromosome t(9;22;11) (q34;q11.2;q13) translocation. She was observed through the remainder of the pregnancy and the disease remained stable; she delivered a normal boy. Treatment with imatinib mesylate was initiated shortly after delivery and she went into molecular complete remission. We discuss the course of the disease and suggest guidelines for managing pregnancy with respect to the currently available agents imatinib, dasatinib and nilotinib.
妊娠期慢性粒细胞白血病的管理需要平衡母亲和胎儿的健康。我们报告一例26岁女性病例，她在妊娠15周时被诊断为慢性粒细胞白血病（CML），并伴有非典型染色体t(9;22;11) (q34;q11.2;q13)易位。在妊娠剩余时间对她进行了观察，疾病保持稳定；她分娩了一个正常男婴。产后不久开始使用甲磺酸伊马替尼治疗，她进入分子学完全缓解状态。我们讨论了该疾病的病程，并就目前可用的药物伊马替尼、达沙替尼和尼洛替尼提出了妊娠期管理指南。
Zotero 插件