抗纤连蛋白抗体与阿尔茨海默病和对照大脑中的斑块及其他结构结合。
Antibodies to fibronectin bind to plaques and other structures in Alzheimer's disease and control brain.
作者信息
Howard J, Pilkington G J
机构信息
Department of Neuropathology, Institute of Psychiatry, London, U.K.
出版信息
Neurosci Lett. 1990 Oct 2;118(1):71-6. doi: 10.1016/0304-3940(90)90251-4.
PMID:2259470
Abstract
Antibodies to fibronectin (Fn) bind not only the basal lamina in Alzheimer's disease brain, but also crystal-like formations in the grey matter, senile plaques, a subset of neuronal perikarya, and large highly processed stellate formations which were both neurofilament and glial fibrillary acidic protein (GFAP) negative and which were identified at a lower frequency in non-demented control brains.
摘要
抗纤连蛋白（Fn）抗体不仅能结合阿尔茨海默病大脑中的基底膜，还能结合灰质中的晶体样结构、老年斑、一部分神经元胞体以及大量高度加工的星状结构，这些星状结构既无神经丝蛋白也无胶质纤维酸性蛋白（GFAP），且在非痴呆对照大脑中的出现频率较低。
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