Department of Dermatology and Venereology, University Hospitals and Medical School of Geneva, Geneva, Switzerland.
Pigment Cell Melanoma Res. 2012 Jul;25(4):482-7. doi: 10.1111/j.1755-148X.2012.01018.x.
Understanding the molecular aberrations involved in the development and progression of metastatic melanoma (MM) is essential for a better diagnosis and targeted therapy. We identified breast cancer suppressor candidate-1 (BCSC-1) as a novel tumor suppressor in melanoma. BCSC-1 expression is decreased in human MM, and its ectopic expression in MM-derived cell lines blocks tumor formation in vivo and melanoma cell proliferation in vitro while increasing cell migration. We demonstrate that BCSC-1 binds to Sox10, which down regulates MITF, and results in a switch of melanoma cells from a proliferative to a migratory phenotype. In conclusion, we have identified BCSC-1 as a tumor suppressor in melanoma and as a novel regulator of the MITF pathway.
了解转移性黑色素瘤（MM）发展和进展中涉及的分子异常对于更好的诊断和靶向治疗至关重要。我们发现乳腺癌抑制候选基因-1（BCSC-1）是黑色素瘤中的一种新型肿瘤抑制因子。BCSC-1 在人 MM 中的表达降低，其在 MM 衍生细胞系中的异位表达可阻断体内肿瘤形成和体外黑色素瘤细胞增殖，同时增加细胞迁移。我们证明 BCSC-1 与 Sox10 结合，下调 MITF，导致黑色素瘤细胞从增殖表型转变为迁移表型。总之，我们已经确定 BCSC-1 是黑色素瘤中的肿瘤抑制因子，也是 MITF 通路的新调节剂。
