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使用深度解析方法检测生物医学事件的修改。

Detecting modification of biomedical events using a deep parsing approach.

机构信息

Department of Computing and Information Systems, University of Melbourne, VIC 3010, Australia.

出版信息

BMC Med Inform Decis Mak. 2012 Apr 30;12 Suppl 1(Suppl 1):S4. doi: 10.1186/1472-6947-12-S1-S4.

DOI:10.1186/1472-6947-12-S1-S4
PMID:22595089
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3339397/
Abstract

BACKGROUND

This work describes a system for identifying event mentions in bio-molecular research abstracts that are either speculative (e.g. analysis of IkappaBalpha phosphorylation, where it is not specified whether phosphorylation did or did not occur) or negated (e.g. inhibition of IkappaBalpha phosphorylation, where phosphorylation did not occur). The data comes from a standard dataset created for the BioNLP 2009 Shared Task. The system uses a machine-learning approach, where the features used for classification are a combination of shallow features derived from the words of the sentences and more complex features based on the semantic outputs produced by a deep parser.

METHOD

To detect event modification, we use a Maximum Entropy learner with features extracted from the data relative to the trigger words of the events. The shallow features are bag-of-words features based on a small sliding context window of 3-4 tokens on either side of the trigger word. The deep parser features are derived from parses produced by the English Resource Grammar and the RASP parser. The outputs of these parsers are converted into the Minimal Recursion Semantics formalism, and from this, we extract features motivated by linguistics and the data itself. All of these features are combined to create training or test data for the machine learning algorithm.

RESULTS

Over the test data, our methods produce approximately a 4% absolute increase in F-score for detection of event modification compared to a baseline based only on the shallow bag-of-words features.

CONCLUSIONS

Our results indicate that grammar-based techniques can enhance the accuracy of methods for detecting event modification.

摘要

背景

这项工作描述了一个系统,用于识别生物分子研究摘要中的事件提及,这些提及要么是推测性的(例如分析 IkappaBalpha 的磷酸化,其中没有指定磷酸化是否发生),要么是否定性的(例如抑制 IkappaBalpha 的磷酸化,其中磷酸化没有发生)。该数据来自为 BioNLP 2009 共享任务创建的标准数据集。该系统使用机器学习方法,其中用于分类的特征是句子单词的浅层特征与基于深度解析器生成的语义输出的更复杂特征的组合。

方法

为了检测事件修饰,我们使用最大熵学习者,其特征是从与事件触发词相关的数据中提取的。浅层特征是基于触发词两侧 3-4 个标记的词袋特征。深度解析器特征来自英语资源语法和 RASP 解析器生成的解析。这些解析器的输出被转换为最小递归语义形式,从中我们提取了受语言学和数据本身启发的特征。所有这些特征都组合在一起,为机器学习算法创建训练或测试数据。

结果

在测试数据上,与仅基于浅层词袋特征的基线相比,我们的方法在检测事件修饰方面的 F 分数提高了约 4%。

结论

我们的结果表明,基于语法的技术可以提高检测事件修饰的方法的准确性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a12/3339397/234868a597b7/1472-6947-12-S1-S4-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a12/3339397/206eaae8593b/1472-6947-12-S1-S4-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a12/3339397/c19cf95e3ba0/1472-6947-12-S1-S4-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a12/3339397/234868a597b7/1472-6947-12-S1-S4-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a12/3339397/206eaae8593b/1472-6947-12-S1-S4-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a12/3339397/c19cf95e3ba0/1472-6947-12-S1-S4-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a12/3339397/234868a597b7/1472-6947-12-S1-S4-3.jpg

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本文引用的文献

1
Semantic classification of diseases in discharge summaries using a context-aware rule-based classifier.使用上下文感知的基于规则的分类器对出院小结中的疾病进行语义分类。
J Am Med Inform Assoc. 2009 Jul-Aug;16(4):580-4. doi: 10.1197/jamia.M3087. Epub 2009 Apr 23.
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The BioScope corpus: biomedical texts annotated for uncertainty, negation and their scopes.生物显微镜语料库:标注了不确定性、否定及其范围的生物医学文本。
BMC Bioinformatics. 2008 Nov 19;9 Suppl 11(Suppl 11):S9. doi: 10.1186/1471-2105-9-S11-S9.
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Exploring hedge identification in biomedical literature.
探索生物医学文献中的对冲识别。
J Biomed Inform. 2008 Aug;41(4):636-54. doi: 10.1016/j.jbi.2008.01.001. Epub 2008 Jan 11.
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A simple algorithm for identifying negated findings and diseases in discharge summaries.一种用于识别出院小结中否定性检查结果和疾病的简单算法。
J Biomed Inform. 2001 Oct;34(5):301-10. doi: 10.1006/jbin.2001.1029.