mRNA 降解途径调控酿酒酵母 Flo11 黏附素表达和生物膜形成。
The mRNA decay pathway regulates the expression of the Flo11 adhesin and biofilm formation in Saccharomyces cerevisiae.
机构信息
Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria 3800, Australia.
出版信息
Genetics. 2012 Aug;191(4):1387-91. doi: 10.1534/genetics.112.141432. Epub 2012 May 17.
Abstract
Regulation of the FLO11 adhesin is a model for gene expression control by extracellular signals and developmental switches. We establish that the major mRNA decay pathway regulates FLO11 expression. mRNA deadenylation of transcriptional repressors of FLO11 by the exonuclease Ccr4 keeps their levels low, thereby allowing FLO11 transcription.
摘要
FLO11 黏附素的调控是细胞外信号和发育开关控制基因表达的模型。我们确定了主要的 mRNA 衰减途径调节 FLO11 的表达。FLO11 的转录阻遏物的 mRNA 去腺苷酸化由外切核酸酶 Ccr4 完成，从而使 FLO11 转录水平保持较低。
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