TP/PD-ECGF 及血小板增多对胃癌的预后价值。

Prognostic value of TP/PD-ECGF and thrombocytosis in gastric carcinoma.

机构信息

Department of Oncology, Xiangyang Central Hospital, Xiangfan University, No. 39, Jingzhou Street, Xiangyang 441021, China.

出版信息

Eur J Surg Oncol. 2012 Jul;38(7):568-73. doi: 10.1016/j.ejso.2012.04.008. Epub 2012 May 15.

DOI:10.1016/j.ejso.2012.04.008

PMID:22595739

Abstract

AIM

Thymidine phosphorylase/platelet-derived endothelial cell growth factor (TP/PD-ECGF) is upregulated in several cancers and plays an important role in angiogenesis and invasion of solid tumors. In this study, we investigated the expression of TP/PD-ECGF in gastric carcinoma and its correlation with clinicopathological features and thrombocytosis, and also determined their prognostic significance.

METHODS

Ninety-eight tissue specimens were resected from patients with gastric carcinoma. The immunohistochemical staining was used for expression of TP/PD-ECGF, platelet counts (PLT) of all patients before surgery were recorded. Patients were divided into high and low TP/PD-ECGF expression groups. Correlations among TP/PD-ECGF expression, PLT and the clinicopathological features of the patients and their prognostic values were studied statistically.

RESULTS

Sixty-one cases of high TP/PD-ECGF expression (62%) and 37 cases of low TP/PD-ECGF expression (38%) were detected. There were 21 patients with thrombocytosis (21%). The results show that high TP/PD-ECGF expression was correlated positively with thrombocytosis (P = 0.046, r = 0.20). The 5-year overall survival rate was 46.0% in patients with low TP/PD-ECGF expression, whereas it was only 14.8% in patients with high TP/PD-ECGF expression (P = 0.000). The 5-year survival rate for patients with and without thrombocytosis were 9.5% and 31.2%, respectively, and there was a significant difference between them (P = 0.0001). The multivariate Cox regression analysis showed that high TP/PD-ECGF expression and thrombocytosis would play a role as independent prognostic factors in patients with gastric carcinoma.

CONCLUSIONS

High TP/PD-ECGF expression and thrombocytosis can be regarded as valuable tools for predicting overall survival in patients with gastric carcinoma.

摘要

目的

胸苷磷酸化酶/血小板衍生的内皮细胞生长因子（TP/PD-ECGF）在多种癌症中上调，在实体肿瘤的血管生成和侵袭中发挥重要作用。本研究调查了 TP/PD-ECGF 在胃癌中的表达及其与临床病理特征和血小板增多的相关性，并确定其预后意义。

方法

从 98 例胃癌患者的组织标本中进行免疫组织化学染色以检测 TP/PD-ECGF 的表达，记录所有患者术前的血小板计数（PLT）。将患者分为高和低 TP/PD-ECGF 表达组。统计分析 TP/PD-ECGF 表达、PLT 与患者临床病理特征的相关性及其预后价值。

结果

检测到 61 例高 TP/PD-ECGF 表达（62%）和 37 例低 TP/PD-ECGF 表达（38%）病例。有 21 例患者血小板增多（21%）。结果表明，高 TP/PD-ECGF 表达与血小板增多呈正相关（P = 0.046，r = 0.20）。低 TP/PD-ECGF 表达患者的 5 年总生存率为 46.0%，而高 TP/PD-ECGF 表达患者的 5 年总生存率仅为 14.8%（P = 0.000）。有和无血小板增多的患者 5 年生存率分别为 9.5%和 31.2%，两者之间有显著差异（P = 0.0001）。多变量 Cox 回归分析表明，高 TP/PD-ECGF 表达和血小板增多是胃癌患者独立的预后因素。