Ekwall E, Svenungsson B
Department of Infectious Diseases, Roslagstull Hospital, Karolinska Institute, Stockholm, Sweden.
Scand J Infect Dis. 1990;22(5):623-4. doi: 10.3109/00365549009027108.
24 patients (4-65 years old; median age 29 years) excreting shigella bacteria greater than 8 weeks were treated with the combination pivampicillin (0.25 g)/pivmecillinam (0.20 g), 2 tablets 3 times a day for 14 days. 23/24 patients (96%) were culture negative after treatment. The one patient that did not respond to treatment carried a strain with intermediate sensitivity to mecillinam and resistance to ampicillin. It is concluded that pivampicillin/pivmecillinam is effective for patients excreting shigella bacteria.
24例（年龄4 - 65岁；中位年龄29岁）排泄志贺氏菌超过8周的患者接受了氨苄青霉素丙酯（0.25g）/匹美西林（0.20g）联合治疗，每日3次，每次2片，共治疗14天。24例患者中有23例（96%）治疗后培养结果为阴性。唯一一例治疗无效的患者携带的菌株对匹美西林中度敏感，对氨苄青霉素耐药。得出的结论是，氨苄青霉素丙酯/匹美西林对排泄志贺氏菌的患者有效。
