Castot A, Benzaken C, Wagniart F, Efthymiou M L
Centre Régional de Pharmacovigilance, Paris Fernand Widal.
Therapie. 1990 Sep-Oct;45(5):399-405.
One hundred and eighty six cases of amineptine abuse were reported to the Regional Centres of Pharmacovigilance or to the Laboratory Eutherapie during a ten year period, between 1978 and february 1988. The analysis was carried out on 155 cases. The principal characteristics of overconsumption are: a predominance of females; the existence of risk factors in 2 out of 3 cases; the absence of correlations between the prescribed dosage, the duration and the importance of abuse; the constant search of a psychostimulant effect; a good clinical acceptability in most cases, but the risk of acne and psychic disturbances must be emphasized; withdrawal difficulties, obtained in only 48 patients (for at least one month). Psychic symptoms on withdrawal were variable and it was not possible to identify a syndrome. The risk of abuse seems to be rare, nevertheless, one must know this occurrence and respect the recommanded dosage. In patients with certain psychiatric illnesses, and especially in patients with risks factors, drugs with stimulant properties should be prescribed with caution.
在1978年至1988年2月的十年间，有186例安咪奈丁滥用病例报告给了地区药物警戒中心或Eutherapie实验室。对其中155例进行了分析。过量服用的主要特征为：女性居多；三分之二的病例存在危险因素；规定剂量、用药时长与滥用程度之间无相关性；持续寻求精神兴奋作用；多数情况下临床接受度良好，但必须强调痤疮和精神障碍的风险；只有48例患者出现撤药困难（至少持续一个月）。撤药时的精神症状各不相同，无法确定一种综合征。滥用风险似乎罕见，然而，必须了解这种情况并遵守推荐剂量。对于患有某些精神疾病的患者，尤其是存在危险因素的患者，应谨慎开具具有兴奋特性的药物。
