Ginestet D, Cazas O, Branciard M
Encephale. 1984;10(4):189-91.
We relate two cases of amineptine (Survector) overconsumption by patients cured for atypical depression with asthenia and activities deficit as the prevalent symptoms. Prescription of two tablets a day (0,200 g) was respected in one case during six months, and in the other case during two years, with therapeutic benefit on apragmatism. To no obvious reason, within few months both patients had gradually raised the doses to twenty tablets (2 g) and thirty tablets (3 g) respectively: we observed subexcitation, insomnia, sensorial hyperaesthesia, irritability, tachyphemia with dysarthria, anorexia with weight lost of more than 10 kg and amphetamine-like troubles without confusion or delusion, as a result of which both patients were treated for their addiction, in hospital. Treatment with clorazepate perfusions did not cause any physical dependence problems. However, psychological dependence was strong enough for one of the patients to go out, on the third day, against medical decision. As far as we know, in France, only one such case of addiction use at high doses and in single intakes is mentioned in the existing literature. However, our observations suggest that it might be necessary to re-assess the place of amineptine among new antidepressive molecules with psychostimulant abilities.
我们讲述了两例服用阿密曲替林（Survector）过量的病例，这两位患者因非典型抑郁症治愈，以乏力和活动能力不足为主要症状。其中一例患者在六个月内每天遵医嘱服用两片（0.200克），另一例在两年内如此服用，对意志缺失有治疗效果。毫无明显原因，几个月内两位患者分别逐渐将剂量增至二十片（2克）和三十片（3克）：我们观察到有轻度兴奋、失眠、感觉过敏、易怒、言语急促伴构音障碍、厌食且体重减轻超过10千克以及类似苯丙胺的症状，但无精神错乱或妄想，因此两位患者均住院接受成瘾治疗。用氯氮卓灌注治疗未引发任何身体依赖问题。然而，心理依赖对其中一位患者来说足够强烈，以至于在第三天违背医嘱出院。据我们所知，在法国，现有文献中仅提及一例如此高剂量单次服用成瘾的病例。然而，我们的观察结果表明，可能有必要重新评估阿密曲替林在具有精神兴奋能力的新型抗抑郁分子中的地位。
