Morland L
Glittre Sanatorium.
Tidsskr Nor Laegeforen. 1990 Nov 20;110(28):3608-11.
The article describes the treatment of tuberculosis in 426 patients over a period of ten years. The length of treatment decreased during the period. The standard treatment was isoniazide and rifampicin, usually with initial administration of pyrazinamide. In pulmonary tuberculosis (n = 334) the median bacteriologic conversion time was five weeks. In 69 patients the medical regimen had to be changed because of side effects. Of the primary antituberculous drugs, isoniazide was the one producing the highest frequency of side effects. 31 patients showed lowered sensitivity to the usual antituberculous drugs and were treated with varying combinations of second line drugs. In two cases surgery was necessary in order to achieve bacteriologic conversion. Ten patients died of tuberculosis in spite of treatment. Five patients with pulmonary tuberculosis suffered a relapse after treatment. No relapse was noted among patients with extrapulmonary tuberculosis. There were large differences between the different pulmonary treatment centres in Eastern Norway as regards how they practised the Norwegian control routines.
这篇文章描述了426例患者在十年期间的结核病治疗情况。在此期间治疗时间缩短。标准治疗方案是异烟肼和利福平，通常初始阶段使用吡嗪酰胺。在肺结核患者（n = 334）中，细菌学转阴的中位时间为五周。69例患者因副作用不得不更改治疗方案。在一线抗结核药物中，异烟肼产生副作用的频率最高。31例患者对常用抗结核药物敏感性降低，接受了二线药物的不同组合治疗。有两例患者需要手术以实现细菌学转阴。尽管接受了治疗，仍有10例患者死于结核病。5例肺结核患者治疗后复发。肺外结核患者未出现复发情况。挪威东部不同的肺部治疗中心在实施挪威控制常规方面存在很大差异。
