[甲氨蝶呤诱发的肺部疾病]
[Methotrexate induced pulmonary disease].
作者信息
Sundset A, Ellingsen I, Bergholtz B
机构信息
Medisinsk avdeling, Aker sykehus, Oslo.
出版信息
Tidsskr Nor Laegeforen. 1990 Nov 20;110(28):3612-4.
PMID:2260058
Abstract
Methotrexate may cause pulmonary side effects. Two cases of methotrexate-induced fibrosing alveolitis are reported. One of the patients died from perforated gastric ulcer, the other was successfully treated with systemic steroids. The pulmonary side effects of methotrexate are reviewed. The most common clinical manifestation is fibrosing alveolitis. Pulmonary fibrosis and acute, non-cardiogenic pulmonary oedema are rare.
摘要
甲氨蝶呤可能会引起肺部副作用。本文报告了两例由甲氨蝶呤诱发的纤维化肺泡炎。其中一名患者死于胃溃疡穿孔，另一名患者通过全身使用类固醇成功治愈。本文对甲氨蝶呤的肺部副作用进行了综述。最常见的临床表现为纤维化肺泡炎。肺纤维化以及急性非心源性肺水肿较为罕见。
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