Magrini G, Iselin H, Ebiner J R, Felber J P
Arch Androl. 1979 Mar;2(2):141-55. doi: 10.3109/01485017908987306.
Some endocrine effects of prolactin (PRL), ACTH, and corticosteroids in testicular function were evaluated by measuring, in normal men, the effects of short-term experimental stimulation and suppression of either plasma PRL levels or adrenal function on plasma androgen profile. PRL levels were increased by administration of metoclopramide or sulpiride or suppressed with bromocryptine. Long-acting testosterone (T) was injected at 8 a.m. on one day in a control period and during a 9-day period of metoclopramide administration. PRL increase was accompanied by a rise in plasma 17-hydroxyprogesterone and T, whereas PRL suppression induced an increase in 5 alpha-dihydrotestosterone (DHT) plasma levels. Peripheral converions of T into DHT and androstenedione, noted after T injection, decreased during concomitant metoclopramide administration. Plasma testicular androgen levels were lowered after long-acting ACTH injections as well as after 24-hr cortisol administration, but the metoclopramide-induced PRL increase appeared to prevent the suppressive effects of ACTH on plasma T. A low-dose dexamethasone treatment did not modify testicular androgen levels. Experimentally induced hyperprolactinemia may have a stimulatory effect on testicular androgen secretion as well as a lowering action on 5 alpha reduction and oxidative T metabolism in man. On the other hand, ACTH-induced androgen suppression seems to be mediated through high circulating levels of corticosteroids; furthermore, PRL and corticosteroids might have reciprocal influences that modulate their effects on testicular function.
通过在正常男性中测量短期实验性刺激和抑制血浆催乳素（PRL）水平或肾上腺功能对血浆雄激素谱的影响，评估了PRL、促肾上腺皮质激素（ACTH）和皮质类固醇对睾丸功能的一些内分泌作用。通过给予甲氧氯普胺或舒必利来升高PRL水平，或用溴隐亭抑制PRL水平。在对照期的某一天上午8点以及在甲氧氯普胺给药的9天期间注射长效睾酮（T）。PRL升高伴随着血浆17-羟孕酮和T的升高，而PRL抑制则导致血浆5α-二氢睾酮（DHT）水平升高。注射T后观察到的T向DHT和雄烯二酮的外周转化在同时给予甲氧氯普胺期间降低。长效ACTH注射后以及给予24小时皮质醇后，血浆睾丸雄激素水平降低，但甲氧氯普胺诱导的PRL升高似乎可防止ACTH对血浆T的抑制作用。低剂量地塞米松治疗未改变睾丸雄激素水平。实验性诱导的高催乳素血症可能对男性睾丸雄激素分泌有刺激作用，同时对5α还原和T的氧化代谢有降低作用。另一方面，ACTH诱导的雄激素抑制似乎是通过高循环水平的皮质类固醇介导的；此外，PRL和皮质类固醇可能具有相互影响，从而调节它们对睾丸功能的作用。
