Siddig M, Ghalib H, Shillington D C, Petersen E A, Khidir S
University of Khartoum, Sudan.
Trop Geogr Med. 1990 Apr;42(2):107-12.
Kala azar is a disease endemic to the Sudan and a cause of major morbidity and mortality to affected patients when the diagnosis or treatment has been delayed. In this report we described the clinical features of 99 parasite proven patients with visceral leishmaniasis. The Sudanese kala azar patient is young in age (teens to 20's), has marked weight loss despite a continuous, excellent appetite and suffers from insomnia, epistaxis and abdominal pain. Hepatosplenomegaly is universally present. Generalized lymphadenopathy is a prominent feature (72%). The high prevalence of lymphadenopathy has a wide range of implications: for diagnosis, i.e., the use of lymph node aspiration; for response to treatment, i.e., the resolution of lymphadenopathy; and for studies of immunoregulation in this systemic infection.
黑热病是苏丹的一种地方病，若诊断或治疗延误，会给受影响患者带来严重的发病和死亡风险。在本报告中，我们描述了99例经寄生虫检测确诊的内脏利什曼病患者的临床特征。苏丹黑热病患者年龄较轻（十几岁到二十几岁），尽管食欲一直很好，但体重明显减轻，且患有失眠、鼻出血和腹痛。普遍存在肝脾肿大。全身性淋巴结病是一个突出特征（72%）。淋巴结病的高发病率具有广泛影响：对于诊断，即使用淋巴结穿刺抽吸；对于治疗反应，即淋巴结病的消退；以及对于这种全身感染的免疫调节研究。
