Ford J L, Rubinstein M H
J Pharm Pharmacol. 1977 Nov;29(11):688-94. doi: 10.1111/j.2042-7158.1977.tb11436.x.
Discs of chlorpropamide and urea have been prepared by (a) melting and (b) compression. Intrinsic and relative dissolution rates of the discs have been measured and the dissolution process investigated microscopically. Higher dissolution rates were found from melts than from physical mixes. The optimum dissolution rate composition found was for a melt composed of 30% w/w chlorpropamide which possessed an intrinsic dissolution rate 930 times greater than for the pure drug. Sphere formation, during dissolution rate measurement has been observed and a likely mechanism proposed to account for its occurrence. Dissolution rates generally increased with age for most melt compositions.
已通过（a）熔融和（b）压制制备了氯磺丙脲和尿素片。测量了该片剂的固有溶出速率和相对溶出速率，并通过显微镜研究了溶出过程。发现熔融物的溶出速率高于物理混合物。发现最佳溶出速率组成是由30% w/w氯磺丙脲组成的熔体，其固有溶出速率比纯药物大930倍。在溶出速率测量过程中观察到了球状物的形成，并提出了一种可能的机制来解释其发生。对于大多数熔体组成，溶出速率通常随时间增加。
