Ford J L, Stewart A F, Rubinstein M H
J Pharm Pharmacol. 1979 Nov;31(11):726-9. doi: 10.1111/j.2042-7158.1979.tb13645.x.
Thin layer chromatography followed by reflectance densitometry has been used to evaluate the stability of chlorpropamide-urea during the fusion process. Urea was found to decompose to biuret and chlorpropamide to p-chlorobenzenesulphonamide: several other unidentified decomposition products were detected. The energy for decomposition of chlorpropamide was 57.1 kJmol-1 for melts containing 15 and 30% chlorpropamide. Decomposition followed apparent first order kinetics.
采用薄层色谱法并结合反射密度测定法来评估氯磺丙脲 - 尿素在熔融过程中的稳定性。发现尿素分解生成缩二脲，氯磺丙脲分解生成对氯苯磺酰胺：还检测到了其他几种未鉴定的分解产物。对于含有15%和30%氯磺丙脲的熔体，氯磺丙脲的分解能量为57.1 kJmol-1。分解遵循表观一级动力学。
