Chan B K Y, Kudsk-Iversen S, Balaguruswamy S, Purewal T S
Department of Endocrinology and General Medicine, Royal Liverpool University Hospital, Liverpool, UK.
BMJ Case Rep. 2012 Apr 4;2012:bcr1120115095. doi: 10.1136/bcr.11.2011.5095.
An elderly lady was admitted for pain management and rehabilitation following a fall. During her stay she developed a new heart murmur and sepsis. Subacute bacterial endocarditits was excluded, empirical ciprofloxacin was initiated and later converted to aztreonam with gentamicin for clinical deterioration. Subsequent investigations revealed meningococcal Y septicaemia secondary to pneumonia, with a possible oropharynx focus. Upon discharge she had returned to baseline state. The case reflects an unusual and increasing cause of pneumonia. A steady increase of infective serogroup Y isolates over the past 12-years in England, with tendency towards elderly makes it a significant differential among the general medical population. This trend corresponds with the US, but is yet unknown whether to be a periodic cycle or true change in dominance and, or, virulence among serogroups. If the latter were true, it would support the inclusion of serogroups beyond menigitides C in the vaccination program.
一位老年女性因跌倒后进行疼痛管理和康复治疗而入院。住院期间,她出现了新的心脏杂音和败血症。排除了亚急性细菌性心内膜炎,开始经验性使用环丙沙星,后来因临床病情恶化改用氨曲南联合庆大霉素。随后的检查发现,肺炎继发脑膜炎球菌Y败血症,可能的感染源为口咽部。出院时她已恢复到基线状态。该病例反映了一种不常见且日益增多的肺炎病因。在过去12年里,英格兰感染性Y血清群分离株稳步增加,且发病倾向于老年人,这使其成为普通内科人群中一个重要的鉴别诊断因素。这种趋势与美国一致,但尚不清楚这是一个周期性循环,还是血清群之间优势地位和/或毒力的真正变化。如果是后者,将支持在疫苗接种计划中纳入除C群脑膜炎球菌之外的血清群。