Kalisnik M, Zorc-Pleskovic R, Pajer Z, Pavlin K
Institute of Histology and Embryology, University Medical Faculty, Ljubljana, Yugoslavia.
Am J Anat. 1990 Nov;189(3):201-6. doi: 10.1002/aja.1001890303.
In three experiments of 30 weeks' duration, 93 adult female Wistar rats received controlled amounts of calcium with food and water, to produce a state of either hypercalcemia or hypocalcemia. A systematic stereological analysis of the thyroid glands and a radioimmunological analysis of thyroxine, triiodothyronine, and thyrotropine were performed. In the hypercalcemic rats, a reactive hyperplasia of the parafollicular cells was established; this was accompanied by morphological and biochemical signs of hyperfunction of the follicular cells, despite a reduced central stimulation by thyrotropin. In the hypocalcemic animals, no quantitative morphological changes in the parafollicular cells were observed; however, morphological and biochemical signs of hypofunction of the follicular cells were obvious, despite stronger central stimulation by thyrotropin. It is concluded that the extrinsic regulation of follicular cells by the blood calcium level is stronger than the intrinsic regulation by hypothalamo-hypophyseal hormones.
在为期30周的三项实验中，93只成年雌性Wistar大鼠通过食物和水摄入受控量的钙，以产生高钙血症或低钙血症状态。对甲状腺进行了系统的体视学分析，并对甲状腺素、三碘甲状腺原氨酸和促甲状腺激素进行了放射免疫分析。在高钙血症大鼠中，建立了滤泡旁细胞的反应性增生；尽管促甲状腺激素的中枢刺激减少，但这伴随着滤泡细胞功能亢进的形态学和生化迹象。在低钙血症动物中，未观察到滤泡旁细胞的定量形态学变化；然而，尽管促甲状腺激素的中枢刺激更强，但滤泡细胞功能减退的形态学和生化迹象明显。得出的结论是，血钙水平对滤泡细胞的外在调节强于下丘脑 - 垂体激素的内在调节。
