Pavlov A V
Morfologiia. 1992 Jun;102(6):99-105.
Slices of the thyroid gland were impregnated with silver nitrate and stained with hematoxylin. Separate calculation of the index of calchicin mitosis of the follicular and parafollicular (C-) cells was made. The material of 37 mature albino rats was analyzed. Calcium-rich diet was given to 22 animals during 10 days. Different levels of hypercalcemia were achieved by different doses of vitamin D2 (from 1 to 10 thousand MU daily, 11 experimental groups). The mitotic index of C-cells was found to grow but under mild hypercalcemia (10% of the control level). Further elevation of the calcium concentration in blood was followed by a decrease of the amount of the dividing parafollicular cells down to control values. In rats fed by the diet optimal for the stimulation of C-cells division (11 rats, 2000 MU as a daily dosage of vitamin D2) within the interval from 1 to 10 days increased mitotic activity of the follicular cells was found from the 3rd day, while that of C-cells only as late as the 9th-10th day. In all the experimental rats the mitotic index of the follicular thyrocytes was 3.5-4 times as high as the mitotic index of C-cells. Relatively not high proliferative activity of parafollicular cells might be due to their pronounced polyfunctional character and their participation in complex paracrine interactions with other cell elements of the thyroid gland.
将甲状腺切片用硝酸银浸染，并用苏木精染色。分别计算滤泡细胞和滤泡旁（C -）细胞的秋水仙素有丝分裂指数。分析了37只成熟白化大鼠的材料。给22只动物喂食富含钙的食物，持续10天。通过不同剂量的维生素D2（每天1至10000 MU，共11个实验组）实现不同程度的高钙血症。发现C细胞的有丝分裂指数在轻度高钙血症（对照水平的10%）时会升高。血液中钙浓度进一步升高后，滤泡旁分裂细胞数量减少至对照值。在喂食对刺激C细胞分裂最适宜饮食的大鼠（11只大鼠，每天维生素D2剂量为2000 MU）中，在1至10天的时间段内，从第3天起发现滤泡细胞的有丝分裂活性增加，而C细胞的有丝分裂活性直到第9 - 10天才增加。在所有实验大鼠中，滤泡甲状腺细胞的有丝分裂指数是C细胞有丝分裂指数的3.5 - 4倍。滤泡旁细胞相对不高的增殖活性可能是由于其明显的多功能特性以及它们参与与甲状腺其他细胞成分的复杂旁分泌相互作用。
