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通过脾细胞功能和NK抗肿瘤活性研究日本香茶菜提取物的免疫调节作用。

Study on the immunomodulation effect of Isodon japonicus extract via splenocyte function and NK anti-tumor activity.

作者信息

Hwang Yu-Jin, Kim Jaehyun, Park Dong-Sik, Hwang Kyung-A

机构信息

Department of Agrofood Resources, National Academy of Agricultural Science, RDA, Suwon 441-853, Korea.

Department of Biotechnology & Bioengineering, Sungkyunkwan University, Suwon 440-746, Korea.

出版信息

Int J Mol Sci. 2012;13(4):4880-4888. doi: 10.3390/ijms13044880. Epub 2012 Apr 18.

DOI:10.3390/ijms13044880
PMID:22606016
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3344252/
Abstract

Here we investigated the potential immune-enhancing activity of Isodon japonicus on murine splenocyte and natural-killer (NK) cells in vitro. The ethanol extract of I. japonicus significantly enhanced the proliferation of splenocyte and induced the significant enhancement of NK cells' activity against tumor cells (YAC-1). In addition, I. japonicus increased the production of interferon (IFN)-γ and tumor necrosis factor (TNF)-α, suggesting that the increase in NK cell cytotoxicity could be due to the enhancement of the NK cell production of both cytokines. Taken together, I. japonicus extract inhibited the growth of human leukemia cells (K562) by 74%. Our observation indicated that the anti-tumor effects of I. japonicus may be attributed to its ability to serve as a stimulant of NK anti-tumor activity. In addition, our results support the development of functional food studies on I. japonicus.

摘要

在此，我们研究了日本香茶菜在体外对小鼠脾细胞和自然杀伤（NK）细胞的潜在免疫增强活性。日本香茶菜的乙醇提取物显著增强了脾细胞的增殖，并诱导NK细胞对肿瘤细胞（YAC-1）的活性显著增强。此外，日本香茶菜增加了干扰素（IFN）-γ和肿瘤坏死因子（TNF）-α的产生，这表明NK细胞细胞毒性的增加可能归因于这两种细胞因子的NK细胞产生增强。综上所述，日本香茶菜提取物使人类白血病细胞（K562）的生长抑制了74%。我们的观察表明，日本香茶菜的抗肿瘤作用可能归因于其作为NK抗肿瘤活性刺激物的能力。此外，我们的结果支持对日本香茶菜进行功能性食品研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418c/3344252/6666a3a29108/ijms-13-04880f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418c/3344252/e1de8faf576f/ijms-13-04880f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418c/3344252/bbc81c5b2777/ijms-13-04880f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418c/3344252/d5fb3e793d4d/ijms-13-04880f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418c/3344252/6666a3a29108/ijms-13-04880f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418c/3344252/e1de8faf576f/ijms-13-04880f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418c/3344252/bbc81c5b2777/ijms-13-04880f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418c/3344252/d5fb3e793d4d/ijms-13-04880f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418c/3344252/6666a3a29108/ijms-13-04880f4.jpg

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