Kawai M, Momoi T, Fujii T, Nakano S, Itagaki Y, Mikawa H
Department of Pediatrics, Kyoto University Faculty of Medicine, Japan.
Am J Med Genet. 1990 Dec;37(4):578-82. doi: 10.1002/ajmg.1320370432.
We report on a 17-year-old Japanese boy with Möbius sequence, peripheral neuropathy, and hypogonadotropic hypogonadism, the fourth such case known to us. The association of peripheral neuropathy and hypogonadotropic hypogonadism in Möbius sequence seems to be more than coincidence. Pulsatile gonadotropin-releasing hormone administration for 3 months showed the effectiveness of this treatment for this patient.
我们报告了一名患有莫比乌斯序列、周围神经病变和低促性腺激素性性腺功能减退的17岁日本男孩，这是我们所知的第四例此类病例。莫比乌斯序列中周围神经病变与低促性腺激素性性腺功能减退的关联似乎并非巧合。对该患者进行为期3个月的脉冲式促性腺激素释放激素给药显示了这种治疗方法的有效性。
