Monawwer Syed Abdullah, Ali Sajjad, Naeem Raahim, Ali Syed Hasan, Rabbani Azkah, Khan Maria, Qazi Saba Saleem, Shah Syed Muhammad Ismail, Farooqui Sabeeh Khawar
Department of Internal Medicine, Ziauddin Medical University, Karachi, Pakistan.
Department of Internal Medicine, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan.
Child Neurol Open. 2023 Oct 18;10:2329048X231205405. doi: 10.1177/2329048X231205405. eCollection 2023 Jan-Dec.
Moebius Syndrome, is a rare, non-progressive congenital neuropathological syndrome characterized primarily by the underdevelopment of the facial (CN VII) and abducens nerve (CN VI). Other features of Moebius Syndrome include facial nerve paresis, ophthalmoplegias, orthodontic deficiencies (including crowded dentition, swollen and hyperplastic gingiva, dental calculus, etc.), musculoskeletal abnormalities, and impaired mental function. Due to the rarity of the disorder, very few case studies have been reported in the literature. This article summarizes the significant features of the disease according to commonalities in reported cases, along with several newly recognized features cited in recent literature. We have explored the different diagnostic criteria and the newly recognized imaging modalities that may be used. Understandably, the condition detrimentally affects a patient's quality of life; thus, treatment measures have also been outlined. This study aims to provide updated literature on Moebius Syndrome MBS and improve understanding of the condition.
梅比厄斯综合征是一种罕见的、非进行性先天性神经病理综合征，主要特征为面神经（CN VII）和展神经（CN VI）发育不全。梅比厄斯综合征的其他特征包括面神经麻痹、眼肌麻痹、正畸缺陷（包括牙列拥挤、牙龈肿胀和增生、牙结石等）、肌肉骨骼异常以及心理功能受损。由于该疾病罕见，文献中报道的病例研究非常少。本文根据已报道病例的共性总结了该疾病的显著特征，以及近期文献中提到的一些新发现的特征。我们探讨了不同的诊断标准和可能使用的新发现的成像方式。可以理解的是，这种情况会对患者的生活质量产生不利影响；因此，也概述了治疗措施。本研究旨在提供有关梅比厄斯综合征（MBS）的最新文献，并增进对该疾病的了解。
