Graham B, Chang S, Lin D, Yakubu F, Hill J O
Department of Pediatrics, Vanderbilt University, Nashville, Tennessee 37232.
Am J Physiol. 1990 Dec;259(6 Pt 2):R1096-102. doi: 10.1152/ajpregu.1990.259.6.R1096.
Weight cycling, defined as repeated episodes of weight loss followed by weight regain, has been suggested to make rats more energy efficient and produce a state of energy balance favoring accumulation of excess body fat. In addition, weight cycling may favor accumulation of fat in central vs. peripheral adipose depots. In the present study, we gave two groups of female Wistar rats ad libitum access to an obesity-producing high-fat diet (60% of calories from fat). Both groups had previously eaten a low-fat stock diet, but one group had been subjected to three bouts of weight cycling. Rats that were previously weight cycled gained less body weight and body fat when given the high-fat diet than did controls. The lower rate of weight gain was due to a lesser increase in food intake, since daily energy expenditure was significantly lower in previously cycled rats than in controls. In summary, weight cycling does not appear to predispose rats to becoming obese on a high-calorie diet and apparently produces some effect on food intake that reduces, at least in the short run, weight gain on the high-calorie diet.
体重循环，定义为体重反复下降后又恢复的情况，有人认为这会使大鼠的能量利用效率更高，并产生一种有利于多余体脂积累的能量平衡状态。此外，体重循环可能更有利于脂肪在中央脂肪库而非外周脂肪库中积累。在本研究中，我们让两组雌性Wistar大鼠随意进食致肥胖的高脂肪饮食（60%的热量来自脂肪）。两组大鼠此前都食用低脂常规饮食，但其中一组经历了三次体重循环。与对照组相比，此前经历过体重循环的大鼠在食用高脂肪饮食时体重和体脂增加较少。体重增加率较低是由于食物摄入量增加较少，因为此前经历过体重循环的大鼠的每日能量消耗明显低于对照组。总之，体重循环似乎不会使大鼠在高热量饮食中更容易肥胖，而且显然会对食物摄入量产生一些影响，至少在短期内会减少高热量饮食时的体重增加。
