University of the Philippines-Philippine General Hospital Section of Dermatology, Taft Avenue, Manila, Philippines.
Int J Dermatol. 2012 Jun;51(6):697-701. doi: 10.1111/j.1365-4632.2011.05219.x.
Verrucous leprosy is rare, with only 18 cases reported in the literature. Visceral involvement is frequent but often overlooked, causing significant morbidity and mortality.
A 45-year-old Filipino male with a 16-year history of hyperpigmented, hypoesthetic plaques, amputated digits, enlarged ulnar nerve, and cardiovascular congestion was diagnosed with Hansen's disease-lepromatous type. He had multiple cauliflower-like nodules and plaques with foul-smelling discharge on the lower extremities presenting a diagnostic dilemma. After an exhaustive search, the causative agent for these verrucous nodules was confirmed to still be Mycobacterium leprae. In addition, he had glomerulonephritis, hypertension, congestive heart failure, deep venous thrombosis, neuritis, keratitis, and glaucoma, which are all complications of advanced leprosy and multiple attacks of erythema nodosum leprosum reactions.
He was treated with a multibacillary regimen of Rifampicin, Dapsone, Clofazimine, and systemic corticosteroids, with remarkable improvement.
疣状麻风罕见，文献中仅报告了 18 例。内脏受累常见但常被忽视，导致严重的发病率和死亡率。
一名 45 岁菲律宾男性，有 16 年的色素沉着、感觉迟钝斑块、截指、尺神经肿大和心血管充血病史，被诊断为汉森病-瘤型麻风。他下肢有多个菜花状结节和斑块，伴有恶臭分泌物，这构成了诊断上的难题。经过详尽的搜索，这些疣状结节的病原体被证实仍然是麻风分枝杆菌。此外，他还患有肾小球肾炎、高血压、充血性心力衰竭、深静脉血栓形成、神经炎、角膜炎和青光眼，这些都是晚期麻风病和多次红斑结节性麻风反应的并发症。
他接受了利福平、氨苯砜、氯法齐明和全身皮质类固醇的多菌型治疗方案，病情显著改善。
