Manusharova R A, Benikova E A, Komissarenko I V, Cheban A K
Akush Ginekol (Mosk). 1990 Aug(8):24-6.
An analysis of gestational and obstetric histories of 40 women with Cushing's disease has shown that pregnancy is contraindicated during an active phase or partial clinical remission of the disease. Pregnancy is permissible at a prolonged time following the onset of a stable clinical and hormonal remission, bilateral total adrenalectomy and compensation of chronic adrenal insufficiency. No specific therapy is required in the former situation. The adrenalectomized patients need an intensification of replacement therapy and switch to parenteral glucocorticoids ante-, intra- and postpartum. Twenty infants of mothers with Cushing's disease were examined and found to have a normal clinical and endocrine status.
对40例库欣病患者的妊娠和产科病史分析表明，在疾病活动期或部分临床缓解期妊娠是禁忌的。在临床和激素稳定缓解、双侧肾上腺全切除及慢性肾上腺功能不全得到代偿后的较长时间可以妊娠。前一种情况无需特殊治疗。肾上腺切除的患者需要强化替代治疗，并在产前、产时和产后改用胃肠外糖皮质激素。对20名库欣病母亲的婴儿进行了检查，发现其临床和内分泌状况正常。
