氨基酸键合表面活性剂：一类新型聚合整体柱的合成家族，为手性毛细管电色谱中的手性分离开辟了可能。
Amino acid bound surfactants: a new synthetic family of polymeric monoliths opening up possibilities for chiral separations in capillary electrochromatography.
机构信息
Center of Diagnostics and Therapeutics, Georgia State University, 50 Decatur Street, Atlanta, Georgia 30303, USA.
出版信息
Anal Chem. 2012 Jun 19;84(12):5236-42. doi: 10.1021/ac300944z. Epub 2012 Jun 7.
Abstract
By combining a novel chiral amino-acid surfactant containing an acryloyl amide tail, a carbamate linker, and a leucine headgroup of different chain lengths with a conventional cross-linker and a polymerization technique, a new "one-pot" synthesis for the generation of amino-acid based polymeric monolith is realized. The method promises to open up the discovery of an amino-acid based polymeric monolith for chiral separations in capillary electrochromatography (CEC). The possibility of enhanced chemoselectivity for simultaneous separation of ephedrine and pseudoephedrine containing multiple chiral centers and the potential use of this amino-acid surfactant bound column for CEC and CEC coupled to mass spectrometric detection are demonstrated.
摘要
通过将一种新型的手性氨基酸表面活性剂与传统的交联剂和聚合技术相结合，该表面活性剂含有丙烯酰胺尾、氨基甲酸酯连接体和不同链长的亮氨酸头基，实现了一种新的“一锅法”氨基酸基聚合物整体柱的合成方法。该方法有望为手性毛细管电色谱（CEC）中的氨基酸基聚合物整体柱的发现开辟新的途径。同时分离含有多个手性中心的麻黄碱和伪麻黄碱的增强化学选择性的可能性，以及将这种氨基酸表面活性剂键合柱用于 CEC 和与质谱检测耦合的 CEC 的潜在用途得到了证明。
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