Centre for Tropical Clinical Pharmacology and Therapeutics, University of Ghana Medical School, P,O, Box GP 4236, Accra, Ghana.
BMC Complement Altern Med. 2012 May 20;12:65. doi: 10.1186/1472-6882-12-65.
Cassia sieberiana is a savannah tree with a wide phytotherapeutic application including the use of its roots in the management of various stomach disorders including gastric ulcer, stomach pains and indigestion. The aim of the study is to evaluate the antioxidant, gastric cytoprotective prostaglandins, secretory phospholipase A2, phytochemical and acute toxicity properties of Cassia sieberiana roots bark extract in a bid to justify its phytotherapeutic applications in gastric ulcer.
Antioxidant and radical scavenging activities of the roots bark extract of Cassia sieberiana were assayed. Serum secretory phospholipase A2 (sPLA2) concentration and activity and the formation of gastric mucosal prostaglandins E2 (PGE2) and I2 (PGI2) were also assessed. Comparisons between means were performed using analysis of variance (ANOVA) followed by Students Standard Newman-Keuls post hoc analysis to determine statistical significance. P < 0.05 was considered significant.
The extract was found to possess significant ferric reducing antioxidant power and can scavenge hydroxyl radicals. The extract also possesses DPPH scavenging activity, can chelate ferrous ion and a dose-dependent protective effect against lipid peroxidation and free radical generation. Prostaglandin studies showed that the roots bark extract dose dependently increased gastric mucosal PGE2 and PGI2 levels and also decreased serum sPLA2 activity. Phytochemical analyses suggest that the roots extract contains polyhydroxyl/phenolic substances. Acute toxicity test showed no sign of toxicity up to a dose level of 2000 mg/kg body weight p.o.
C. sieberiana roots extract possesses significant antioxidant and gastric cytoprotective prostaglandin properties as well as serum secretory phospholipase A2 inhibitory activity which could be due to its content of polyhydroxy and/or phenolic substances. This may justify its use as an anti-ulcerogenic agent in traditional medicine in West Africa.
决明子是一种热带草原树种，具有广泛的植物治疗应用，包括使用其根来治疗各种胃部疾病，如胃溃疡、胃痛和消化不良。本研究旨在评估决明子根皮提取物的抗氧化、胃细胞保护前列腺素、分泌型磷脂酶 A2、植物化学物质和急性毒性特性，以证明其在胃溃疡中的植物治疗应用。
测定了决明子根皮提取物的抗氧化和自由基清除活性。还评估了血清分泌型磷脂酶 A2（sPLA2）浓度和活性以及胃黏膜前列腺素 E2（PGE2）和 I2（PGI2）的形成。使用方差分析（ANOVA）进行均值比较，然后使用学生标准纽曼-凯尔斯事后分析确定统计学意义。P<0.05 被认为具有统计学意义。
提取物具有显著的铁还原抗氧化能力，并能清除羟基自由基。提取物还具有 DPPH 清除活性，能螯合亚铁离子，并具有剂量依赖性的保护作用，可防止脂质过氧化和自由基生成。前列腺素研究表明，根皮提取物剂量依赖性地增加胃黏膜 PGE2 和 PGI2 水平，并降低血清 sPLA2 活性。植物化学分析表明，根提取物含有多羟基/酚类物质。急性毒性试验表明，在 2000mg/kg 体重口服剂量下无毒性迹象。
决明子根提取物具有显著的抗氧化和胃细胞保护前列腺素特性以及血清分泌型磷脂酶 A2 抑制活性，这可能与其多羟基和/或酚类物质的含量有关。这可能证明其在西非传统医学中作为抗溃疡剂的用途。
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