Department of Medical Histology and Cell Biology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Department of Biochemistry, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, Egypt.
J Mol Histol. 2022 Jun;53(3):573-587. doi: 10.1007/s10735-022-10072-y. Epub 2022 Mar 15.
Cinnamon is one of the herbal resources belonging to the Lauraceae family, is commonly used in traditional medicine and as a flavoring agent. It has antioxidant and anti-inflammatory activities. Therefore, the present study was performed to evaluate the gastroprotective effect of cinnamon on ethanol-induced gastric ulcer in comparison to omeprazole. In Wistar rats, gastric ulcers were induced using one oral dose of 70% ethanol (5 ml/kg b. w.) Cinnamon oil at doses of 2.5 ml/kg body weight and omeprazole (a reference drug) at a dose of 20 mg/kg body weight were orally administrated daily for 7 days before ulcer induction. 1 h after ethanol administration blood samples were collected and then the stomachs of sacrificed rats were subjected to biochemical, macroscopic and histological, and immunohistochemical studies. Oral administration of cinnamon oil significantly attenuated gastric ulcer as revealed by a significant increase in the gastric levels of enzymatic and non-enzymatic antioxidants namely CAT, SOD, GSH-Px, and GSH with a concomitant reduction in MDA level compared with those in the ethanol group. Pre-treatment of cinnamon oil markedly improved the level of TNF-α and PGE content. Furthermore, cinnamon oil pre-treatment significantly increased the immunoreactivity of VEGF while decreasing the immunoreactivity of COX-II. These results were further supported by histopathological findings which revealed the curing effect of cinnamon oil on the microscopic changes induced by ethanol toxicity. Cinnamon oil showed a potential gastroprotective effect on ethanol-induced gastric ulcer comparable to the gastroprotective effect of omeprazole, and its effect may be mediated through suppression of oxidative stress and gastric inflammation and promotion of angiogenesis.
肉桂是樟科植物的一种草药资源，常用于传统医学和调味剂。它具有抗氧化和抗炎作用。因此，本研究旨在评估肉桂对乙醇诱导的胃溃疡的胃保护作用，并与奥美拉唑进行比较。在 Wistar 大鼠中，使用 70%乙醇（5 ml/kg b.w.）口服诱导胃溃疡。肉桂油以 2.5 ml/kg 体重和奥美拉唑（参考药物）以 20 mg/kg 体重的剂量分别在溃疡诱导前每天口服给药 7 天。乙醇给药 1 小时后采集血样，然后对处死大鼠的胃进行生化、宏观和组织学以及免疫组织化学研究。肉桂油的口服给药显著减轻了胃溃疡，表现为胃中酶和非酶抗氧化剂 CAT、SOD、GSH-Px 和 GSH 的水平显著增加，而 MDA 水平与乙醇组相比降低。肉桂油预处理显著提高了 TNF-α 和 PGE 含量。此外，肉桂油预处理显著增加了 VEGF 的免疫反应性，同时降低了 COX-II 的免疫反应性。这些结果得到了组织病理学发现的进一步支持，这些发现揭示了肉桂油对乙醇毒性引起的微观变化的治疗作用。肉桂油对乙醇诱导的胃溃疡具有潜在的胃保护作用，与奥美拉唑的胃保护作用相当，其作用可能通过抑制氧化应激和胃炎症以及促进血管生成来介导。
