患者患有急性早幼粒细胞白血病，发生围手术期维 A 酸综合征。

Perioperative retinoic acid syndrome in a patient with acute promyelocytic leukemia.

机构信息

Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

出版信息

J Clin Anesth. 2012 Jun;24(4):315-7. doi: 10.1016/j.jclinane.2011.10.009.

DOI:10.1016/j.jclinane.2011.10.009

Abstract

All-trans retinoic acid (ATRA), a vitamin A derivative, is prescribed for induction of chemotherapy in patients with acute promyelocytic leukemia. Like other chemotherapy agents, ATRA has an adverse effect known as retinoic acid syndrome. The case of a 22 year old woman with acute promyelocytic leukemia, who received ATRA and subsequently developed retinoic acid syndrome, is presented. The patient's symptoms resolved after administration of dexamethasone, allowing the completion of chemotherapy without further complications.

摘要

全反式维 A 酸（ATRA）是一种维生素 A 衍生物，用于诱导急性早幼粒细胞白血病患者进行化疗。与其他化疗药物一样，ATRA 有一个已知的不良反应，称为维 A 酸综合征。本文报告了一例 22 岁女性急性早幼粒细胞白血病患者，在接受 ATRA 治疗后出现维 A 酸综合征。患者的症状在给予地塞米松后得到缓解，使化疗得以顺利完成，没有出现进一步的并发症。