[肝肾功能对大剂量甲氨蝶呤（MTX）治疗中血清MTX水平变化的影响]
[The influence of liver and renal functions on the changes in serum methotrexate (MTX) level in high-dose MTX therapy].
作者信息
Sato T, Nakanishi K, Takahashi M, Sato K, Miura T, Kuzuya T, Mizuno M
机构信息
Dept. of Orthopaedic Surgery, Nagoya University, School of Medicine.
出版信息
Gan To Kagaku Ryoho. 1990 Dec;17(12):2375-9.
Sixty times of high dose methotrexate (MTX) with citrovorum factor rescue (HDMTX-CF) therapy were applied for 15 patients with osteosarcoma. The serum level of MTX was measured at every 24 hr. by FPIA (Fluorescence Polarization Immuno Assay) method and blood analysis was performed at the same time. Fourtysix parameters were measured in each HDMTX-CF therapy and examined by multiple parameter statistical analyses by a personal computer. In the results, the number of performed chemotherapy, rescue time, serum GOT and creatinine level at 24 hr. were the most relative factors for the change of serum MTX level.
对15例骨肉瘤患者应用60次大剂量甲氨蝶呤（MTX）联合亚叶酸钙解救（HDMTX - CF）疗法。每24小时通过荧光偏振免疫分析（FPIA）法测定血清MTX水平，并同时进行血液分析。每次HDMTX - CF疗法测量46项参数，并通过个人计算机进行多参数统计分析。结果显示，化疗次数、解救时间、24小时时的血清谷草转氨酶（GOT）和肌酐水平是血清MTX水平变化的最相关因素。
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