Miyauchi Y, Mii Y, Morishita T, Miura S, Honoki K, Aoki M, Kido A, Tamai S, Hino M, Nomura Y, Nakanishi E
Dept. of Orthopedic Surgery, Nara Medical University, Japan.
Gan To Kagaku Ryoho. 1996 Apr;23(5):595-9.
For 5 osteosarcomas and one synovial sarcoma, 24 courses of high-dose methotrexate (MTX) therapy were performed. At MTX doses of 300 mg/kg with several infusion patterns, the plasma MTX concentrations were measured by fluorescence polarization immunoassay. In the various types of infusions, five hours oblique and five hours bolus infusions were well maintained at 1,000 micromol/l for several hours. In particular, five hours bolus infusion of MTX needed only 20 minutes to reach 822 micromol/l and maintained 1,000 micromol/l during almost the entire infusion period. Optimization of chemotherapy for sarcomas by MTX requires individual adaptation of the infusion pattern.
对于5例骨肉瘤和1例滑膜肉瘤，进行了24个疗程的大剂量甲氨蝶呤（MTX）治疗。在MTX剂量为300mg/kg并采用多种输注方式时，通过荧光偏振免疫测定法测量血浆MTX浓度。在各种输注类型中，5小时斜向输注和5小时推注输注在数小时内均能很好地维持在1000微摩尔/升。特别是，MTX的5小时推注输注仅需20分钟即可达到822微摩尔/升，并在几乎整个输注期间维持在1000微摩尔/升。通过MTX对肉瘤化疗进行优化需要根据个体情况调整输注方式。
