突尼斯慢性乙肝表面抗原携带者中的德尔塔感染：在慢性无症状乙肝表面抗原携带者和乙肝表面抗原阳性肝硬化患者中患病率较高。

Delta infection in chronic HBs Ag carriers in Tunisia: high prevalence in chronic asymptomatic HBs Ag carriers and in HBs Ag positive cirrhosis.

作者信息

Jenhani F, Ayed K, Gorgi Y, Zoulim F, Pichoud C, Trepo C

机构信息

Laboratoire d'Immunologie, Faculté de Médecine de Tunis, Tunisia.

出版信息

Ann Trop Med Parasitol. 1990 Aug;84(4):349-53. doi: 10.1080/00034983.1990.11812479.

DOI:10.1080/00034983.1990.11812479

PMID:2260899

Abstract

The presence of hepatitis B virus DNA, delta antigen and anti-delta antibodies was examined in 159 Tunisian chronic HBs Ag carriers: 45 were asymptomatic and 114 suffered from cirrhosis. Serum hepatitis B virus DNA was detected in two (4.5%) asymptomatic HBs Ag carriers and in 11 (10%) HBs Ag positive cirrhosis patients. The prevalence of HDV infection determined by the presence of anti-delta was relatively high in asymptomatic HBs Ag carriers (33%) and in HBs Ag positive cirrhosis patients (21%). Active ongoing HDV infection, detected by serum HD Ag and anti-delta IgM, was shown in five patients with cirrhosis and active hepatitis B virus replication. We conclude that hepatitis delta virus may be endemic in Tunisia and does not always inhibit hepatitis B virus replication.

摘要

对159名突尼斯慢性乙肝表面抗原携带者检测了乙肝病毒DNA、丁型抗原和抗丁型抗体：45名无症状，114名患有肝硬化。在两名（4.5%）无症状乙肝表面抗原携带者和11名（10%）乙肝表面抗原阳性肝硬化患者中检测到血清乙肝病毒DNA。由抗丁型抗体的存在所确定的丁型肝炎病毒感染率在无症状乙肝表面抗原携带者中（33%）和乙肝表面抗原阳性肝硬化患者中（21%）相对较高。通过血清丁型抗原和抗丁型IgM检测到，五名患有肝硬化且乙肝病毒活跃复制的患者存在正在进行的丁型肝炎病毒活跃感染。我们得出结论，丁型肝炎病毒在突尼斯可能为地方性流行，且并不总是抑制乙肝病毒复制。