Iguchi H, Ueda M, Sakamoto T, Yamada M, Torii S
Division of Pediatrics, National Chubu Hospital.
Arerugi. 1990 Oct;39(10):1388-96.
Recently, moulds are considered to be important allergens for bronchial asthma. To confirm this fact, 76 asthmatic patients (mean age 12.5, range 6-17 years) admitted to National Chubu Hospital were investigated for 16 different mould allergens by Pharmacia RAST RIA to measure specific-IgE for moulds. The results were as follows. 1) The frequency of positive RASTs (score greater than or equal to 2) varied from 4% to 21% depending on the allergen. Because 21 patients were RAST positive to one or more allergens, ultimately 26 patients (34%) appeared to be RAST positive to more than one of the 16 mould allergens. 2) According to the number of positive RASTs, the patients were divided into 3 groups, i.e. group 1 with more than five, group 2 with less than four and group 3 with zero. The ratio of patients with severe and moderate asthma to the total subjects was not significantly different between three groups before admission, but significantly high in group 1 and group 2 in order compared to groups 3 (chi 2(4)df = 18.81, p less than 0.005) one year after admission. This tendency was already apparent even one month after admission. 3) The frequency of positive RASTs for mould allergens was higher in patients with atopic dermatitis than in those without it. From these results, positive RAST for mould allergen seems to have considerable influence to intractable asthma and atopic dermatitis in young asthmatic patients.
最近，霉菌被认为是支气管哮喘的重要过敏原。为证实这一事实，对入住中部国立医院的76例哮喘患者（平均年龄12.5岁，范围6 - 17岁），采用Pharmacia RAST RIA检测16种不同霉菌过敏原的特异性IgE。结果如下：1）根据过敏原不同，RAST阳性（评分大于或等于2）的频率在4%至21%之间变化。由于21例患者对一种或多种过敏原RAST呈阳性，最终26例患者（34%）似乎对16种霉菌过敏原中的一种以上RAST呈阳性。2）根据RAST阳性的数量，将患者分为3组，即5个以上阳性的第1组、少于4个阳性的第2组和0个阳性的第3组。入院前3组中重度和中度哮喘患者占总受试者的比例无显著差异，但入院一年后，第1组和第2组与第3组相比，该比例依次显著升高（χ2(4)df = 18.8），p < 0.005）。甚至在入院一个月后这种趋势就已经很明显。3）特应性皮炎患者霉菌过敏原RAST阳性频率高于无特应性皮炎的患者。从这些结果来看，霉菌过敏原RAST阳性似乎对年轻哮喘患者的难治性哮喘和特应性皮炎有相当大的影响。
