Kaufman E E, Porrino L J, Nelson T
Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, MD 20892.
Biochem Pharmacol. 1990 Dec 15;40(12):2637-40. doi: 10.1016/0006-2952(90)90581-5.
gamma-Hydroxybutyrate (GHB) has been found to have a biphasic effect on body temperature with increased body temperature after low doses (5-10 mg/kg) and decreased body temperature after high doses (300-500 mg/kg). Brain levels of GHB between 30 and 60 min post-injection of GHB were not altered by the low doses (5-10 mg/kg), although a dose of 200 mg/kg produced a large increase in the brain concentration.
已发现γ-羟基丁酸（GHB）对体温有双相作用，低剂量（5 - 10毫克/千克）后体温升高，高剂量（300 - 500毫克/千克）后体温降低。注射GHB后30至60分钟，低剂量（5 - 10毫克/千克）不会改变大脑中GHB的水平，尽管200毫克/千克的剂量会使大脑浓度大幅增加。
