γ-羟基丁酸及其拮抗剂NCS-382对大鼠前额叶皮质自发细胞放电的影响。
Effect of gamma-hydroxybutyrate and its antagonist NCS-382 on spontaneous cell firing in the prefrontal cortex of the rat.
作者信息
Godbout R, Jelenic P, Labrie C, Schmitt M, Bourguignon J J
机构信息
Département de psychiatrie Université de Montréal, Qué., Canada.
出版信息
Brain Res. 1995 Feb 27;673(1):157-60. doi: 10.1016/0006-8993(94)01461-p.
Gamma-hydroxybutyrate (GHB) at low doses (5-10 mg/kg i.p.) increased and at high doses (160-320 mg/kg i.p.) decreased the spontaneous firing rate of prefrontal cortex (PFC) neurons recorded in urethane-anesthetized rats. Only excitations were blocked by NCS-382, a specific GHB receptor antagonist; this suggests that the excitatory effect of low doses of GHB is mediated by a GHB receptor whereas the inhibitory effect of high doses of GHB involves a more complex mechanism.
在乌拉坦麻醉的大鼠中，低剂量（腹腔注射5 - 10毫克/千克）的γ-羟基丁酸（GHB）会增加前额叶皮质（PFC）神经元的自发放电率，而高剂量（腹腔注射160 - 320毫克/千克）则会降低该放电率。只有兴奋作用被特异性GHB受体拮抗剂NCS - 382阻断；这表明低剂量GHB的兴奋作用是由GHB受体介导的，而高剂量GHB的抑制作用涉及更复杂的机制。
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