Laboratory of Genetic and Environmental Epidemiology, Research Laboratories, Fondazione di Ricerca e Cura "Giovanni Paolo II" Catholic University, Campobasso, Italy.
Eur J Prev Cardiol. 2013 Oct;20(5):862-71. doi: 10.1177/2047487312447904. Epub 2012 May 18.
Pulmonary dysfunction could influence the onset and the evolution of cardiovascular disorders. This study evaluated whether pulmonary dysfunction based on spirometry, plethysmography and carbon monoxide diffusion test is associated with the estimated risk of cardiovascular disease in 10 years.
We performed a cross-sectional general population-based cohort study.
The Moli-sani Project is a population-based cohort study of subjects aged ≥35 years, randomly recruited from the general population in Italy. Cardiovascular risk in 10 years was predicted by the CUORE score which provides an estimate of the probability of a first coronary or cerebrovascular event in the next 10 years, based on a risk equation derived from Italian cohorts. Out of 12,933 subjects with high-quality flow/volume manoeuvre, 8,132 subjects had suitable plethysmography and 3,422 carbon monoxide diffusion (carbon monoxide alveolar diffusion test [DLCO]).
In multivariate analyses, reduced pulmonary function expressed by forced vital capacity (FVC), forced expiratory volume in the first second (FEV1) and total lung capacity (TLC) were inversely associated with CUORE score both in men and in women, independently of other risk factors such as age, height, smoking habits, total cigarettes exposure (pack-years), pulmonary disease, body mass index, social status and physical activity. In contrast, there was no association between FEV1/FVC ratio, residual volume, DLCO and CUORE risk score.
In both genders from an adult general Italian population, pulmonary function decline is associated with increased cardiovascular risk. These results suggest that pulmonary monitoring could be useful to more accurately predict cardiovascular risk.
肺功能障碍可能影响心血管疾病的发生和发展。本研究评估了基于肺量计、体积描记法和一氧化碳弥散试验的肺功能障碍与 10 年内心血管疾病估计风险之间的关系。
我们进行了一项横断面基于一般人群的队列研究。
Moli-sani 项目是一项基于人群的队列研究，研究对象为年龄≥35 岁的人群，随机从意大利一般人群中招募。10 年内的心血管风险由 CUORE 评分预测，该评分根据源自意大利队列的风险方程，提供了未来 10 年内首次发生冠状动脉或脑血管事件的概率估计。在 12933 名具有高质量流量/体积操作的受试者中，8132 名受试者有合适的体积描记法，3422 名受试者进行了一氧化碳弥散（一氧化碳肺泡弥散试验[DLCO]）。
在多变量分析中，用力肺活量（FVC）、第 1 秒用力呼气量（FEV1）和肺总量（TLC）降低的肺功能与 CUORE 评分呈负相关，无论男性还是女性，都独立于年龄、身高、吸烟习惯、总吸烟量（包年）、肺部疾病、体重指数、社会地位和体力活动等其他危险因素。相比之下，FEV1/FVC 比值、残气量、DLCO 与 CUORE 风险评分之间没有关联。
在来自意大利一般成年人群的男女中，肺功能下降与心血管风险增加相关。这些结果表明，肺监测可能有助于更准确地预测心血管风险。
