Shapira Udi, Krubiner Mor, Ehrenwald Michal, Shapira Itzhak, Zeltser David, Berliner Shlomo, Rogowski Ori, Shenhar-Tsarfaty Shani, Bar-Shai Amir
Department of Internal Medicine C, D and E, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Division of Pulmonary Medicine, Barzilai Medical Center, Faculty of Health Sciences, Ben-Gurion University, Ashkelon, Israel,
Int J Chron Obstruct Pulmon Dis. 2019 Mar 7;14:597-603. doi: 10.2147/COPD.S192594. eCollection 2019.
While chronic respiratory diseases are among the leading causes of mortality and morbidity worldwide, little is known about the effect of blood eosinophil levels on lung function trajectories among healthy individuals.
We analyzed data of apparently healthy individuals (n=18,089) recruited for the Tel Aviv Medical Center Inflammation Survey. Blood eosinophil levels were compared between participants with normal and those with abnormal lung function. Multivariate regression was used to assess the OR of forced expiratory volume in 1 second (FEV) deterioration according to baseline eosinophils in subjects with normal lung function (n=4,141) during a follow-up period of 4 years.
Participants with an abnormal, as opposed to a normal, pulmonary function test (PFT) (n=1,832, 10.1%) had significantly higher eosinophil levels, expressed as a percentage or count (2.99%±2.00% compared to 2.67%±1.88% and 0.2210e3/µL±0.163/µL compared to 0.1810e3/µL±0.183/µL, respectively; <0.001 for both). Among participants with a normal PFT at baseline, those with an eosinophil percentage higher than 4% showed a higher risk for FEV decline above 60 mL/year (OR=1.199, 95% CI=1.005-1.431, =0.044).
Our study suggests that higher blood eosinophil levels can predict PFT deterioration even in apparently healthy subjects, implying that these individuals could benefit from frequent lung function evaluation.
虽然慢性呼吸道疾病是全球死亡和发病的主要原因之一，但关于血液嗜酸性粒细胞水平对健康个体肺功能轨迹的影响知之甚少。
我们分析了为特拉维夫医疗中心炎症调查招募的明显健康个体（n = 18,089）的数据。比较了肺功能正常和异常参与者的血液嗜酸性粒细胞水平。采用多变量回归评估肺功能正常的受试者（n = 4,141）在4年随访期间根据基线嗜酸性粒细胞水平1秒用力呼气量（FEV）恶化的比值比。
肺功能测试（PFT）异常的参与者（n = 1,832，10.1%）与正常参与者相比，嗜酸性粒细胞水平显著更高，以百分比或计数表示（分别为2.99%±2.00% 与2.67%±1.88%，以及0.22×10³/µL±0.163/µL与0.18×10³/µL±0.183/µL；两者均P<0.001）。在基线PFT正常的参与者中，嗜酸性粒细胞百分比高于4%的参与者FEV下降超过60 mL/年的风险更高（比值比=1.199，95%置信区间=1.005 - 1.431，P = 0.044）。
我们的研究表明，即使在明显健康的受试者中，较高的血液嗜酸性粒细胞水平也可预测PFT恶化，这意味着这些个体可能受益于频繁的肺功能评估。
