Department of Internal Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
J Intensive Care Med. 2012 Nov-Dec;27(6):384-8. doi: 10.1177/0885066611429661. Epub 2012 May 19.
Burst-suppression pattern on electroencephalography (EEG) occurs upon dissociation of the cortex from underlying brain structures. Unless the pattern is a physiologic consequence of administered sedatives, this electroencephalographic pattern is indicative of a poor neurologic outcome and high mortality. We report a case of a 29-year-old female thought to be brain dead based on initial physical examination and EEG findings of burst-suppression, who was later found to have supratherapeutic serum levels of bupropion. This is the second documented case of burst-suppression pattern on EEG in a patient who overdosed on bupropion. We propose that burst-suppression in the setting of bupropion toxicity may revert with drug clearance.
脑电图（EEG）上出现爆发抑制模式表明皮质与脑内结构分离。除非该模式是给予镇静剂的生理后果，否则这种脑电图模式表明神经预后不良和死亡率高。我们报告了一例 29 岁女性的病例，根据初始体格检查和 EEG 发现的爆发抑制，认为她处于脑死亡状态，但后来发现她的安非他酮血清水平高于治疗范围。这是第二例因安非他酮中毒而出现 EEG 爆发抑制模式的患者。我们提出，安非他酮毒性作用下的爆发抑制可能随着药物清除而逆转。
