消胆胺对原发性IIA型高脂蛋白血症患者脂蛋白脂质的影响。

The effect of cholestyramine on lipoprotein lipids in patients with primary type IIA hyperlipoproteinemia.

作者信息

Weisweiler P, Neureuther G, Schwandt P

出版信息

Atherosclerosis. 1979 Jul;33(3):295-300. doi: 10.1016/0021-9150(79)90181-3.

Abstract

The effect of 3 months' treatment with cholestyramine on lipoprotein lipids was investigated in 12 patients. VLDL, LDL and HDL were separated by preparative ultracentrifugation. There was a significant decrease of serum cholesterol and phospholipids and an increase of serum triglycerides. All the VLDL-lipids increased by nearly 30%. The LDL-lipids decreased with a tendency for normalisation of their atypical lipid composition. The small but significant alterations of HDL triglycerides and cholesterol are correlated with the corresponding alterations of the other lipoproteins; the HDL-phospholipids were unchanged. The LDL/HDL-lipid ratios were decreased but not normalised. The 30% decrease of LDL-cholesterol is negatively correlated with an increase in all the VLDL-lipids.

摘要

在12例患者中研究了考来烯胺治疗3个月对脂蛋白脂质的影响。通过制备性超速离心法分离极低密度脂蛋白（VLDL）、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）。血清胆固醇和磷脂显著降低，血清甘油三酯升高。所有VLDL脂质增加了近30%。LDL脂质减少，其非典型脂质组成有正常化趋势。HDL甘油三酯和胆固醇的微小但显著变化与其他脂蛋白的相应变化相关；HDL磷脂未改变。LDL/HDL脂质比值降低但未恢复正常。LDL胆固醇降低30%与所有VLDL脂质增加呈负相关。