Section of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA.
Dig Dis Sci. 2012 Jul;57(7):1954-8. doi: 10.1007/s10620-012-2214-4. Epub 2012 May 19.
Groove pancreatitis is a segmental form of chronic pancreatitis that can be treated with pancreaticoduodenectomy (PD), although outcome studies for this approach are lacking. We performed an assessment of pain symptoms, need for opioids, and weight gain following PD for symptomatic groove pancreatitis.
The study was a retrospective case series describing all patients with groove pancreatitis who underwent PD at our medical center. The primary outcome was the change in pain level and opioid use following PD.
Five patients underwent PD for treatment of groove pancreatitis. Patients' perception of pain, using a 10-point visual analog scale, improved after surgery from 5.0 to 0.2. Opioid analgesics, as measured by oral morphine equivalents, dropped from 77.6 to 0 mg daily, with all five patients being completely free of opioids post-operatively. Weight loss ceased in all five patients, with an overall mean weight gain of 15.4 pounds post-operatively.
PD reduces pain and opioid analgesic use in groove pancreatitis. This intervention should be considered for patients with this condition.
沟槽性胰腺炎是一种节段性慢性胰腺炎,可以通过胰十二指肠切除术(PD)进行治疗,尽管缺乏针对这种方法的疗效研究。我们对 PD 治疗有症状的沟槽性胰腺炎后的疼痛症状、阿片类药物需求和体重增加进行了评估。
该研究是一项回顾性病例系列研究,描述了在我们医疗中心接受 PD 治疗的所有沟槽性胰腺炎患者。主要结局是 PD 后疼痛程度和阿片类药物使用的变化。
5 名患者因沟槽性胰腺炎接受 PD 治疗。患者的疼痛感知,使用 10 分制视觉模拟评分法,术后从 5.0 分降至 0.2 分。阿片类镇痛药(以口服吗啡当量衡量)从 77.6 毫克降至 0 毫克/天,所有 5 名患者术后均完全无需使用阿片类药物。5 名患者的体重均不再减轻,术后总体平均体重增加 15.4 磅。
PD 可减轻沟槽性胰腺炎的疼痛和阿片类药物的使用。对于这种疾病的患者,应考虑采用这种干预措施。