Department of General Thoracic Surgery, Tongji Hospital Attached to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People's Republic of China.
Environ Toxicol. 2014 May;29(5):596-603. doi: 10.1002/tox.21785. Epub 2012 May 19.
Di-(2-ethylhexyl)-Phthalate (DEHP) can affect glucose and insulin homeostasis in periphery and lead to insulin resistance, especially exposure of DEHP during critical developmental period. Given the potential relationship between insulin resistance and pathogenesis of Alzheimer's disease (AD) in elderly life, we investigated the relationship between perinatal DEHP exposure and AD pathogenesis. Our results suggested that perinatal exposure to DEHP can affect the expression of insulin and insulin-Akt- GSK-3β signal pathway in hippocampus. Furthermore, impaired cognitive ability and increased level of phospho-Tau was observed in DEHP-exposed rat offspring (1.25 ± 0.11 vs. 0.47 ± 0.07, P < 0.05). The present study demonstrates that perinatal exposure to DEHP may be a potential risk factor for AD pathogenesis associated with insulin resistance and insulin metabolism disorder in the hippocampus.
邻苯二甲酸二（2-乙基己基）酯（DEHP）可影响外周葡萄糖和胰岛素稳态，导致胰岛素抵抗，尤其是在关键发育期接触 DEHP。鉴于老年期胰岛素抵抗与阿尔茨海默病（AD）发病机制之间存在潜在关系，我们研究了围产期 DEHP 暴露与 AD 发病机制之间的关系。我们的结果表明，围产期 DEHP 暴露可影响海马组织中胰岛素和胰岛素-Akt-GSK-3β信号通路的表达。此外，在 DEHP 暴露的大鼠后代中观察到认知能力受损和磷酸化 Tau 水平升高（1.25±0.11 与 0.47±0.07，P＜0.05）。本研究表明，围产期 DEHP 暴露可能是 AD 发病机制的潜在危险因素，与海马组织中胰岛素抵抗和胰岛素代谢紊乱有关。
