邻苯二甲酸二（2-乙基己基）酯对中枢神经系统功能的影响：一项叙述性综述。
Effects of Di-2-Ethylhexyl Phthalate on Central Nervous System Functions: A Narrative Review.
机构信息
Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
Department of Pharmacology and Toxicology, Babol University of Medical Sciences, Babol, Iran.
出版信息
Curr Neuropharmacol. 2022;20(4):766-776. doi: 10.2174/1570159X19666210713122517.
BACKGROUND
Phthalates are widely used in the plastics industry. Di-2-Ethylhexyl Phthalate (DEHP) is one of the most important phthalate metabolites that disrupt the function of endocrine glands. Exposure to DEHP causes numerous effects on animals, humans, and the environment. Low doses of DEHP increase neurotoxicity in the nervous system that has arisen deep concerns due to the widespread nature of DEHP exposure and its high absorption during brain development.
OBJECTIVE
In this review article, we evaluated the impacts of DEHP exposure from birth to adulthood on neurobehavioral damages. Then, the possible mechanisms of DEHP-induced neurobehavioral impairment were discussed.
METHODOLOGY
Peer-reviewed articles were extracted through Embase, PubMed, and Google Scholar till the year 2021.
RESULTS
The results showed that exposure to DEHP during pregnancy and infancy leads to memory loss and irreversible nervous system damage.
CONCLUSION
Overall, it seems that increased levels of oxidative stress and inflammatory mediators possess a pivotal role in DEHP-induced neurobehavioral impairment.
背景
邻苯二甲酸酯广泛应用于塑料工业。邻苯二甲酸二（2-乙基）己酯（DEHP）是最重要的邻苯二甲酸代谢物之一，它会破坏内分泌腺的功能。DEHP 暴露对动物、人类和环境都有许多影响。低剂量的 DEHP 会增加神经系统的神经毒性，由于 DEHP 暴露的广泛性及其在大脑发育过程中的高吸收率，这引起了人们的深切关注。
目的
在这篇综述文章中，我们评估了从出生到成年期 DEHP 暴露对神经行为损伤的影响。然后，讨论了 DEHP 引起的神经行为损伤的可能机制。
方法
通过 Embase、PubMed 和 Google Scholar 提取了截至 2021 年的同行评审文章。
结果
结果表明，在妊娠和婴儿期暴露于 DEHP 会导致记忆力丧失和神经系统不可逆转的损伤。
结论
总的来说，似乎氧化应激和炎症介质水平的增加在 DEHP 引起的神经行为损伤中起着关键作用。
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