Smiley Dawn, Chandra Prakash, Umpierrez Guillermo E
Emory University School of Medicine, Division of Endocrinology & Metabolism, Atlanta, GA 30303, USA.
Diabetes Manag (Lond). 2011 Nov 1;1(6):589-600. doi: 10.2217/DMT.11.57.
Diabetic ketoacidosis (DKA) has been considered a key clinical feature of Type 1 diabetes mellitus; however, increasing evidence indicates that DKA is also a common feature of Type 2 diabetes (T2DM). Many cases of DKA develop under stressful conditions such as trauma or infection but an increasing number of cases without precipitating cause have been reported in children and adults with T2DM. Such patients present with severe hyperglycemia and ketosis as in Type 1 diabetes mellitus but can discontinue insulin after a few months and maintain acceptable glycemic control on diet or oral agents. This subtype of diabetes has been referred to as ketosis-prone T2DM. In this article, we reviewed the literature on ketosis-prone T2DM and summarized the epidemiology, putative pathophysiology and approaches to management.
糖尿病酮症酸中毒（DKA）一直被认为是1型糖尿病的关键临床特征；然而，越来越多的证据表明，DKA也是2型糖尿病（T2DM）的常见特征。许多DKA病例在创伤或感染等应激条件下发生，但在患有T2DM的儿童和成人中，无诱发因素的病例报告越来越多。这类患者表现出与1型糖尿病类似的严重高血糖和酮症，但几个月后可以停用胰岛素，并通过饮食或口服药物维持可接受的血糖控制。这种糖尿病亚型被称为酮症倾向型T2DM。在本文中，我们回顾了关于酮症倾向型T2DM的文献，并总结了其流行病学、假定的病理生理学和管理方法。
