Paredes Joana, Figueiredo Joana, Albergaria André, Oliveira Patrícia, Carvalho Joana, Ribeiro Ana Sofia, Caldeira Joana, Costa Angela Margarida, Simões-Correia Joana, Oliveira Maria José, Pinheiro Hugo, Pinho Salomé S, Mateus Rita, Reis Celso A, Leite Marina, Fernandes Maria Sofia, Schmitt Fernando, Carneiro Fátima, Figueiredo Céu, Oliveira Carla, Seruca Raquel
University of Porto, Porto, Portugal.
Biochim Biophys Acta. 2012 Dec;1826(2):297-311. doi: 10.1016/j.bbcan.2012.05.002. Epub 2012 May 19.
E-cadherin and P-cadherin are major contributors to cell-cell adhesion in epithelial tissues, playing pivotal roles in important morphogenetic and differentiation processes during development, and in maintaining integrity and homeostasis in adult tissues. It is now generally accepted that alterations in these two molecules are observed during tumour progression of most carcinomas. Genetic or epigenetic alterations in E- and P-cadherin-encoding genes (CDH1 and CDH3, respectively), or alterations in their proteins expression, often result in tissue disorder, cellular de-differentiation, increased invasiveness of tumour cells and ultimately in metastasis. In this review, we will discuss the major properties of E- and P-cadherin molecules, its regulation in normal tissue, and their alterations and role in cancer, with a specific focus on gastric and breast cancer models.
E-钙黏蛋白和P-钙黏蛋白是上皮组织中细胞间黏附的主要贡献者，在发育过程中的重要形态发生和分化过程以及维持成体组织的完整性和稳态中发挥关键作用。现在普遍认为，在大多数癌症的肿瘤进展过程中会观察到这两种分子的改变。E-钙黏蛋白和P-钙黏蛋白编码基因（分别为CDH1和CDH3）的遗传或表观遗传改变，或其蛋白质表达的改变，通常会导致组织紊乱、细胞去分化、肿瘤细胞侵袭性增加，并最终导致转移。在本综述中，我们将讨论E-钙黏蛋白和P-钙黏蛋白分子的主要特性、它们在正常组织中的调节以及它们在癌症中的改变和作用，特别关注胃癌和乳腺癌模型。
