University of Pittsburgh School of Dental Medicine, Pittsburgh, PA, USA.
Caries Res. 2012;46(4):346-52. doi: 10.1159/000338851. Epub 2012 May 17.
Caries remains the most prevalent noncontagious biofilm-mediated disease in humans. It is clear that the current approaches to decrease the prevalence of caries in human populations, including water fluoridation and school-based programs, are not enough to protect everyone. The scientific community has suggested the need for innovative work in a number of areas in cariology, encompassing disease etiology, epidemiology, definition, prevention, and treatment. In this symposium, two of these areas, dealing specifically with etiological aspects of caries were discussed: (1) systematic research on caries risk assessment using population-based cohort techniques, and (2) genetic studies to identify genes and genetic markers of diagnostic, prognostic, and therapeutic value. This paper summarizes these presentations.
龋齿仍然是人类最普遍的非传染性生物膜介导疾病。显然,目前减少人群中龋齿患病率的方法,包括水氟化和学校为基础的项目,还不足以保护每个人。科学界已经提出需要在龋病的许多领域进行创新工作,包括疾病病因学、流行病学、定义、预防和治疗。在本次专题讨论会上,讨论了与龋齿病因学方面相关的两个领域:(1)使用基于人群的队列技术对龋齿风险评估进行系统研究;(2)基因研究以确定具有诊断、预后和治疗价值的基因和遗传标记。本文总结了这些演讲。