釉基质衍生物（Emdogain）联合骨陶瓷对犬下颌骨缺损骨形成的影响：一项组织形态计量学和免疫组织化学研究
The effect of an enamel matrix derivative (Emdogain) combined with bone ceramic on bone formation in mandibular defects: a histomorphometric and immunohistochemical study in the canine.
作者信息
Birang Reza, Abouei Mohammad Shah, Razavi Sayed Mohammad, Zia Peyaman, Soolari Ahmad
机构信息
Department of Periodontics, School of Dentistry and Torabinejad Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
ScientificWorldJournal. 2012;2012:196791. doi: 10.1100/2012/196791. Epub 2012 Apr 24.
BACKGROUND
The purpose of this study was to evaluate the combination of an enamel matrix derivative (EMD) and an osteoconductive bone ceramic (BC) in improving bone regeneration.
MATERIALS AND METHODS
Four cylindrical cavities (6 × 6 mm) were prepared bilaterally in the mandible in three dogs. The defects were randomly assigned to four different treatments-filled with EMD/BC and covered with a nonresorbable membrane, filled with EMD/BC without membrane, membrane coverage only, or control (left untreated)-and healed for 2, 4, or 6 weeks. Harvested specimens were prepared for histologic, histomorphometric, and immunohistochemical analyses.
RESULTS
Sites treated with EMD/BC with or without membrane showed more total bone formation and lamellar bone formation than membrane-only and control defects. There were no statistically significant differences in total bone formation between EMD/BC with or without membrane.
CONCLUSION
EMD with BC might improve bone formation in osseous defects more than membrane coverage alone; the use of a membrane had no significant additive effect on total bone formation.
背景
本研究的目的是评估牙釉质基质衍生物（EMD）和骨传导性骨陶瓷（BC）联合使用对改善骨再生的效果。
材料与方法
在三只犬的下颌骨双侧制备四个圆柱形骨腔（6×6毫米）。将缺损随机分为四种不同处理——填充EMD/BC并覆盖不可吸收膜、填充EMD/BC但不覆盖膜、仅覆盖膜或对照组（不做处理）——并分别愈合2、4或6周。对采集的标本进行组织学、组织形态计量学和免疫组织化学分析。
结果
使用或未使用膜的EMD/BC处理部位比仅覆盖膜和对照组缺损显示出更多的总体骨形成和板层骨形成。使用或未使用膜的EMD/BC之间在总体骨形成方面无统计学显著差异。
结论
EMD与BC联合使用可能比单独覆盖膜更能改善骨缺损处的骨形成；使用膜对总体骨形成无显著附加作用。
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