Kanmura Shuji, Sakiyama Toshio, Uto Hirofumi, Tsubouchi Hirohito
Department of Pathology, Keck School of Medicine, University of Southern California.
Nihon Rinsho. 2012 May;70(5):790-5.
Inflammatory bowel diseases (IBD), which includes ulcerative colitis and Crohn's disease, are chronic intestinal disorders of unknown etiology. The diagnosis of IBD is based upon clinical history, endoscopic, and histological findings; however, accurate diagnosis can still be difficult with these current methodologies. Recent advances in molecular techniques in proteomics and genetic analysis have driven the discovery of novel IBD biomarkers and genetic susceptibility factors that may facilitate the diagnosis of IBD. In the future, biomarkers will play a key role in the diagnosis of IBD and the development of individual courses of treatment.
炎症性肠病（IBD）包括溃疡性结肠炎和克罗恩病，是病因不明的慢性肠道疾病。IBD的诊断基于临床病史、内镜检查和组织学检查结果；然而，使用这些现有方法仍可能难以进行准确诊断。蛋白质组学和基因分析等分子技术的最新进展推动了新型IBD生物标志物和遗传易感性因素的发现，这些因素可能有助于IBD的诊断。未来，生物标志物将在IBD的诊断和个体化治疗方案的制定中发挥关键作用。
