Center for Stem Cell and Regenerative Medicine, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, TX, USA.
Drug Discov Today. 2013 Jun;18(11-12):567-73. doi: 10.1016/j.drudis.2012.05.008. Epub 2012 May 22.
Obesity has long been recognized as a risk factor for diabetes and cardiovascular disease. Recent epidemiological data also associate obesity with cancer risk and progression. For this reason, a combination treatment of obesity along with treatment of the cancer itself may improve patient survival and well-being. As the molecular pathways linking obesity and cancer become better understood, new potential therapy targets are surfacing. In this article, we summarize the mechanisms proposed to account for the obesity-cancer association and discuss approaches to manipulation of adipose tissue as potential interventions aimed at cancer prevention or supplemental therapy.
肥胖长期以来一直被认为是糖尿病和心血管疾病的一个风险因素。最近的流行病学数据还将肥胖与癌症风险和进展联系起来。出于这个原因，肥胖的联合治疗以及癌症本身的治疗可能会提高患者的生存率和生活质量。随着肥胖与癌症之间的分子途径变得更加清晰，新的潜在治疗靶点也在浮现。在本文中，我们总结了解释肥胖与癌症之间关联的机制，并讨论了操纵脂肪组织的方法，这些方法可能成为预防癌症或辅助治疗的潜在干预手段。
