Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN, USA.
Br J Haematol. 2012 May;157(4):472-5. doi: 10.1111/j.1365-2141.2012.09075.x.
Previously, we reported increased risk of heavy-chain (HC) monoclonal gammopathy of undetermined significance (MGUS) among first-degree (1°) relatives of multiple myeloma (MM) or HC-MGUS probands. This study investigated whether there was comparable risk for light-chain (LC) MGUS among 911 relatives of the same HC-MGUS/MM probands versus a reference population of 21 463. Seventeen 1° relatives had LC-MGUS (adjusted prevalence = 1·7%, 95% CI = 0·9–2·6%). There was increased risk of LC-MGUS in relatives of MM probands (RR = 3·4, 95% CI = 2·0–5·5). We saw no increased risk in relatives of HC-MGUS probands. We conclude that the prevalence of LC-MGUS is significantly higher among 1° relatives of MM probands compared to the reference population.
此前，我们报道称多发性骨髓瘤（MM）或重链（HC）单克隆丙种球蛋白异常血症（MGUS）先证者一级亲属（1°）发生 HC-MGUS 的风险增加。本研究调查了在同一 HC-MGUS/MM 先证者的 911 名亲属与 21463 名参考人群相比，轻链（LC）MGUS 是否存在可比风险。17 名 1°亲属患有 LC-MGUS（调整患病率=1.7%，95%CI=0.9-2.6%）。MM 先证者亲属发生 LC-MGUS 的风险增加（RR=3.4，95%CI=2.0-5.5）。我们在 HC-MGUS 先证者亲属中未发现风险增加。我们的结论是，与参考人群相比，MM 先证者一级亲属的 LC-MGUS 患病率明显更高。
