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beta 2-Adrenoceptors in rat liver microcirculation.

作者信息

Koo A, Liang I Y

出版信息

Clin Exp Pharmacol Physiol. 1979 Jul-Aug;6(4):403-7. doi: 10.1111/j.1440-1681.1979.tb00027.x.

DOI:10.1111/j.1440-1681.1979.tb00027.x
PMID:226301
Abstract
  1. Rat liver sinusoids were observed by a microscopic in vivo transillumination method. The diameter of liver sinusoids and intrasinusoid erythrocyte flow velocities were measured quantitatively by a close-circuit television technique. 2. Both isoprenaline and the selective beta 2-adrenoceptor agonist terbutaline produced a concentration-dependent dilatation of liver sinusoids and slowed erythrocyte flow velocity. The effects of isoprenaline and terbutaline were antagonized by propranolol but not by the selective beta 1-adrenoceptor antagonist atenolol. Propranolol alone produced constriction of the liver sinusoids and increased erythrocyte flow velocity; these effects were not produced by atenolol. 3. The percentage dilatations produced by isoprenaline alone, isoprenaline in the presence of phenoxybenzamine and isoprenaline in the presence of phenylephrine-induced constriction were similar. 4. It is proposed that the beta-adrenoceptors in liver sinusoids are of the beta 2-type, and their physiological role was to counteract constrictor responses produced by alpha-adrenoceptor activity.
摘要

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