文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Koo A, Liang I Y, Cheng K K

Clin Exp Pharmacol Physiol. 1976 Jul-Aug;3(4):391-5. doi: 10.1111/j.1440-1681.1976.tb00616.x.

Specific alpha- and beta-adrenoreceptor agonists, phenylephrine and isoprenaline, were injected intraportally into the intact rat liver under direct microscopic observation by an in vivo transillumination technique. 2. The diameter of a hepatic sinusoid and the intra-sinusoidal erythrocyte velocity were quantitatively measured, and the sinusoidal volume flow was calculated from these two parameters. 3. Results show that phenylephrine causes a sinusoidal constriction and an increased sinusoidal blood flow, whereas isoprenaline causes the opposite effects on the sinusoids. 4. All the sinusoidal responses to phenylephrine and isoprenaline were dose-dependent and were possibly related to the direct effect of these drugs on the sinusoids.

在体内透照技术的直接显微镜观察下，将特定的α和β肾上腺素能受体激动剂去氧肾上腺素和异丙肾上腺素经门静脉注射到完整大鼠肝脏中。2. 定量测量肝血窦直径和血窦内红细胞速度，并根据这两个参数计算血窦容积流量。3. 结果表明，去氧肾上腺素引起血窦收缩和血窦血流增加，而异丙肾上腺素对血窦产生相反的作用。4. 血窦对去氧肾上腺素和异丙肾上腺素的所有反应均呈剂量依赖性，可能与这些药物对血窦的直接作用有关。

Koo A, Liang I Y, Cheng K K

Clin Exp Pharmacol Physiol. 1976 Jul-Aug;3(4):391-5. doi: 10.1111/j.1440-1681.1976.tb00616.x.

Specific alpha- and beta-adrenoreceptor agonists, phenylephrine and isoprenaline, were injected intraportally into the intact rat liver under direct microscopic observation by an in vivo transillumination technique. 2. The diameter of a hepatic sinusoid and the intra-sinusoidal erythrocyte velocity were quantitatively measured, and the sinusoidal volume flow was calculated from these two parameters. 3. Results show that phenylephrine causes a sinusoidal constriction and an increased sinusoidal blood flow, whereas isoprenaline causes the opposite effects on the sinusoids. 4. All the sinusoidal responses to phenylephrine and isoprenaline were dose-dependent and were possibly related to the direct effect of these drugs on the sinusoids.

在体内透照技术的直接显微镜观察下，将特定的α和β肾上腺素能受体激动剂去氧肾上腺素和异丙肾上腺素经门静脉注射到完整大鼠肝脏中。2. 定量测量肝血窦直径和血窦内红细胞速度，并根据这两个参数计算血窦容积流量。3. 结果表明，去氧肾上腺素引起血窦收缩和血窦血流增加，而异丙肾上腺素对血窦产生相反的作用。4. 血窦对去氧肾上腺素和异丙肾上腺素的所有反应均呈剂量依赖性，可能与这些药物对血窦的直接作用有关。